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Bibliografia
Diagnostic Role of
Immunogenetics in Post-Vaccine Diseases of the Central Nervous System (CNS): Preliminary Results
Associazione Universo Bambino - Italy
Massimo G.
Montinari, Biagio Favoino”, Angela
Roberto”
* Servizio di Tipizzazione tessutale e trapianti d'organo - Azienda Ospedaliera
Policlinico di Bari, Italy
** Ambulatorio di Virologia -
Azienda Ospedaliera Policlinico di Bari, Italy
The Mediterranean Journal of
Surgery and Medecine
Abstract
We report of 30 patients with post-vaccine diseases of CNS and other organs who
presented with the initial symptoms at the time of or immediately a.fter vaccines.
All patients were tested for Herpes virtis (IgG and IgM) and tissue typing (HLA A,
B, C, HLA DR-DQ) to study the relationship between the development of post-vaccine CNS
diseases and those antigens trying to show that an immunogenetic substrate (autoimmune
type) is involved in demyeiination processes.
The comparison of our patients with formai Italian controis showed an increased
presence of HLA A3 and DR-7 antigens in the former group. The occurrence of A3 and/or DR7
was observed in 22/30 patients (73.3%)
Key words: Post-vaccine disease - HLA antigens
-Autoinimune disease CNS
Résumé
Cette étude rapporte l’observation de 30 patients atteints de pathologies
post-vaccinaies intéressant le SNC et d’autres systèmes dans lesquels ies premiers
symptòmes sont apparus concomitamment ou immédiatement après l’administration de
vaccins.
Chez tous les patients on a effectué des recherches sérologiques pour les virus
herpétiques (IgG et IgM) ainsi qu’une caractérisation tissulaire HLA (A,B,C) et
HLA-DR-DQ afin de mettre en évidence tine corrélation possible entre l’apparition
de pathologies citi SNC et ces antigènes; autoimmunitaires du SNC
cette corrélation pourrait expliquer une éventuelle base immunogénétique de
type autoimrnunitaire dans les processus de démyélinisation. La comparaison statistique
avec la population italienne de contròle a mis en évidence une augmentation des
antigènes HLA-A3 et HLA-DR-7. On a observé la présence de A3 et/ou DR-7 chez 22/30
(73,3%) patients.
Mots-clés: Pathologies post-vaccinales - Système HLA
- pathologies
Riassunto
Lo studio si riferisce all’osservazione di 30 pazienti affetti da patologie
post-vaccinali con interessamento del SNC e di altri apparati nei quali i primi sintomi
sono insorti in concomitanza o immediatamente dopo la somministrazione di vaccini.
Tutti i pazienti sono stati sottoposti ad indagini sierologiche per virus erpetici
(IgG e IgM) nonché a tipizzazione tessutale HLA(A,B,C) e HLA-DR-DQ allo scopo di
accertare una eventuale correlazione tra l’insorgenza di patologie a carico del SNC e
questi antigeni tale da spiegare una possibile base immunogenetica di tipo autoimmunitario
nei processi di demielinizzazione. Il confronto statistico con la popolazione italiana di
controllo ha messo in evidenza un aumento degli antigeni HLA-A3 e HLADR-7.
La presenza
di A3 e/o DR-7 è stata osservata in 22/30 (73,3%) dei pazienti.
Parole chiave: Patologie post-vaccinali - sistema HLA
- patologie autoimnuinitarie del SNC
INTRODUCTION
CNS post-vaccine diseases are often not well studied.Recently,
it has been suggested the “occurrence of CNS demyelination follwing immunisation with
recombinant Hepatitis B vaccine” (1) ancl these observation have heen supported by
other Investigators who reported “lack of virus and eosinophiiia following
recombinant Hepatitis B vaccine” (2). These studies induced us to reevaiuate patients
who presented with netirological symptoms followingn immunisation already investigated in
several Itaiian and European Centres.
Med. J. Surg. Mcd. 2 (1996), 69-72
